Low frequency stimulation evokes serotonin release in the nucleus
نویسندگان
چکیده
4 Costanza Burattini*, Giulia Battistini, Francesco Tamagnini, Giorgio Aicardi 5 Department for Life Quality Studies and Interdepartmental Centre “Luigi Galvani” for the Study 6 of Biophysics, Bioinformatics and Biocomplexity, University of Bologna, Bologna, Italy. 7 8 Author contributions 9 C.B.: conception and design of the experiments, collection, analysis and interpretation of data, 10 preparation of figures, drafting and critical revision of the manuscript. G.B.: collection, analysis and 11 interpretation of data, preparation of figures, critical revision of the manuscript. F.T.: collection and 12 interpretation of data, statistical analysis, critical revision of the manuscript; G.A.: conception and 13 design of experiments, interpretation of data and critical revision of the manuscript. 14 15 Running head: serotonin mediates eCB-LTD in the NAc 16 Number of pages: 31 17 Number of figures: 5 18 Number of tables: 3 19 Number of words in Abstract: 234 20 Number of words in Introduction: 591 21 Number of words in Discussion: 1340 22 23
منابع مشابه
Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid.
The nucleus accumbens (NAc), a major component of the mesolimbic system, is involved in the mediation of reinforcing and addictive properties of many dependence-producing drugs. Glutamatergic synapses within the NAc can express plasticity, including a form of endocannabinoid (eCB)-long-term depression (LTD). Recent evidences demonstrate cross talk between eCB signaling pathways and those of oth...
متن کاملEffect of Electrical Stimulation and Lesion of Nucleus Accumbens on EEG of Intact and Addicted Rats
Introduction: The nucleus accumbens is involved in various functions ranging from motivation and reward to feeding and drug addiction. Some researchers have also suggested that this region has some roles in consciousness. In the present study, the effect of electrical stimulation and lesion of nucleus accumbens on Electroencephalogram waves (EEG) of addict and non-addict rats was investigated. ...
متن کاملReview of Metabolism, Transport and Role of Serotonin in the Body and the Relation between Serotonin and Diseases
Serotonin (5-hydroxytriptamine), one of the most important neurotransmitters, is synthesized from amino acid L-tryptophan in some neurons located in the central nervous system and intestine enterochromaffin cells . The role of this neurotransmitter is important and involves control of sexual behaviors, morality, sleep, pain, appetite, aggression, cardiovascular function and regulation of gut fu...
متن کاملOpposite change of in vivo dopamine release in the rat nucleus accumbens and striatum that follows electrical stimulation of dorsal raphe nucleus: role of 5-HT3 receptors.
In the present study we investigate, using in vivo microdialysis, the involvement of central 5-HT3 receptors in the effect of dorsal raphe nucleus (DRN) electrical stimulation on dopamine (DA), 3, 4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindole-3-acetic acid (5-HIAA) extracellular levels monitored in the nucleus accumbens and the striatum of halothane-anesthetized rats. DRN stimulatio...
متن کامل5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade.
The effect of blockade of either 5-hydroxytryptamine (5-HT)/serotonin transporter (SERT) with citalopram or the organic cation transporter 3 (OCT3)/plasma membrane monoamine transporter (PMAT) with decynium-22 (D-22) on spontaneous and evoked release of 5-HT in the nucleus tractus solitarius (NTS) was investigated in rat brainstem slices treated with gabazine. 5-HT release was measured indirect...
متن کامل